Sunday

DAWN tutorial
In case you were ever clamoring to know more about how the DAWN system of gathering data works, SAMHSA just posted an on-line tuitorial for both the Emergency Department guidelines (for folks who wander in because of "drug-related" reasons) and the Medical Examiner guidelines (when the drug use led to death):

ED Version:
http://edcbtt.e-dawn.net/

ME Version:
https://mecbtt.e-dawn.net/index.php
Click on the "New Users: Click HERE to begin" to create a user name (email address) and password.


animals in abuse liability
Review article about whether animal abuse liability studies can be interpreted as we think usually do.
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http://www.sciencedirect.com/science?_ob=ArticleURL%26_udi=B6T1J-4HG69XB-3%26_user=861681%26_handle=V-WA-A-W-WD-MsSAYVA-UUW-U-AAVEACZEUE-AAVZDBDDUE-YBEUEDVBW-WD-U%26_fmt=full%26_coverDate=12%252F05%252F2005%26_rdoc=4%26_orig=browse%26_srch=%2523toc%25234892%25232005%2523994739998%2523612554!%26_cdi=4892%26view=c%26_acct=C000046147%26_version=1%26_urlVersion=0%26_userid=861681%26md5=53c714a4aa54b51b52848c9b6890df93

European Journal of Pharmacology Volume 526, Issues 1-3 , 5 December 2005, Pages 9-20 The Neuropsychopharmacology of Aggression and Addiction
Imbalance between drug and non-drug reward availability: A major risk factor for addiction
Serge H. Ahmed

Abstract
Laboratory animals self-administer most, though not all, drugs of abuse.
Recent evidence shows that with increased drug availability, most laboratory rats develop all the major behavioral signs of addiction, including:
1) drug intake escalation,
2) increased motivation for the drug,
3) difficulty to abstain,
4) decreased reward function, and
5) inflexible drug use.
The large prevalence of addicted rats may suggest that they are particularly vulnerable to develop compulsive drug use. I review evidence showing that this apparent vulnerability results in large part from the lack of positive (i.e., alternative non-drug rewards) and negative (i.e., costs) incentives capable of turning animals away from the pursuit of drugs.
In particular, most animals seem to take drugs and eventually become addicted, not because drugs are intrinsically addictive, but more likely because drugs are the only significant sources of reward available in the laboratory.
Laboratory animals would therefore represent more of a model of high-risk human groups than of the general population.
Consequently, they should be more suited for searching factors that protect from, rather than predispose to, drug addiction.
Reconsidering the environmental background of drug self-administration experiments in laboratory animals raises intriguing implications for understanding the initial demand for drug consumption and the transition to drug addiction, and for extrapolation from laboratory animals to humans.

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